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ModerateEndocrinologyPrimary hypothyroidismuk-plab-1

A 62-year-old woman presents with fatigue, weight gain, cold intolerance and constipation. Her TSH is 18 mU/L (normal 0.4–4.0) and free T4 is low. She has no history of ischaemic heart disease and weighs 70 kg. What is the most appropriate starting dose of Levothyroxine?

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