Question

A 61-year-old man with type 2 diabetes and hypertension has an eGFR of 65 mL/min/1.73 m² and an albumin-to-creatinine ratio (ACR) of 6 mg/mmol on two occasions. What is the most appropriate pharmacological intervention to reduce his risk of progression of kidney disease and cardiovascular events?

Accepted Answer

Start an ACE inhibitor such as Ramipril, titrating to the maximum tolerated dose.

Answer

Add a thiazide diuretic such as Bendroflumethiazide.

Answer

Start a non-dihydropyridine calcium-channel blocker such as Verapamil.

Answer

No drug therapy is indicated because his eGFR is normal.

Answer

Start an SGLT2 inhibitor alone without ACE inhibitor therapy.

Practice question

A 61-year-old man with type 2 diabetes and hypertension has an eGFR of 65 mL/min/1.73 m² and an albumin-to-creatinine ratio (ACR) of 6 mg/mmol on two occasions. What is the most appropriate pharmacological intervention to reduce his risk of progression of kidney disease and cardiovascular events?