Question

A 68-year-old man with known ischaemic heart disease and heart failure is prescribed Gentamicin for suspected gram-negative sepsis. He has an eGFR of 25 mL/min/1.73 m². According to BNF principles, what is the most appropriate approach to Gentamicin dosing?

Accepted Answer

Adjust dose or dosing interval based on renal function and monitor serum Gentamicin levels closely.

Answer

Use standard once-daily dosing without adjustment.

Answer

Avoid Gentamicin completely in any renal impairment.

Answer

Use the same dose but add a loop diuretic to protect the kidneys.

Answer

Give an extra loading dose because of reduced renal clearance.

Practice question

A 68-year-old man with known ischaemic heart disease and heart failure is prescribed Gentamicin for suspected gram-negative sepsis. He has an eGFR of 25 mL/min/1.73 m². According to BNF principles, what is the most appropriate approach to Gentamicin dosing?