Question

A 74-year-old man with newly diagnosed non-valvular atrial fibrillation has a CHA₂DS₂-VASc score of 4. He has no contraindications to anticoagulation and normal renal function. According to NICE guidance, what is the most appropriate stroke prevention strategy?

Accepted Answer

Start a direct oral anticoagulant such as Apixaban at an appropriate dose.

Answer

No antithrombotic therapy is required because aspirin is sufficient.

Answer

Start aspirin 75 mg once daily alone.

Answer

Start warfarin with a target INR of 1.5–2.0.

Answer

Start dual antiplatelet therapy with aspirin and clopidogrel.

Practice question

A 74-year-old man with newly diagnosed non-valvular atrial fibrillation has a CHA₂DS₂-VASc score of 4. He has no contraindications to anticoagulation and normal renal function. According to NICE guidance, what is the most appropriate stroke prevention strategy?