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ModerateRespiratoryAcute exacerbation of COPDuk-plab-1

A 70-year-old man with a 40-pack-year smoking history presents with increasing breathlessness and sputum purulence over 3 days. He has known COPD with FEV1 45% predicted. On examination he is using accessory muscles, respiratory rate 26 breaths per minute, oxygen saturation 89% on air and there are widespread wheezes. What is the most appropriate initial oxygen therapy strategy?

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