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ModerateRespiratoryAcute exacerbation of COPDuk-plab-1

A 63-year-old man with known COPD presents with increased breathlessness, purulent sputum and wheeze. He uses a Salbutamol inhaler and a tiotropium inhaler at home. Observations: RR 26/min, SpO2 88% on air, pH 7.32, PaCO2 7.5 kPa on arterial blood gas. Which is the most appropriate initial oxygen therapy?

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