A 35-year-old man with known asthma presents with wheeze and shortness of breath. He can speak in short phrases, respiratory rate is 30/min, heart rate 115 bpm, PEFR is 45% of best, and oxygen saturation is 93% on air. He has had three nebulised Salbutamol treatments and oral Prednisolone in the last hour with little improvement. What is the most appropriate next step?