A 22-year-old man with sickle cell disease presents with severe generalised bone pain, fever 38 degrees Celsius and tachycardia. He is not hypoxic and his chest is clear. What is the most important initial management component?AWithhold opioids to avoid dependenceBStart strong opioid analgesia with adequate hydration and consider antibioticsCStart Hydroxycarbamide therapy acutelyDRestrict fluids to avoid pulmonary oedemaEArrange urgent exchange transfusion for all painful crisesCheck my answer