ModerateCardiovascularHeart failure with reduced ejection fractionuk-plab-1
A 70-year-old woman presents with shortness of breath on exertion, orthopnoea and bilateral ankle oedema. Echocardiography confirms heart failure with reduced ejection fraction. Her blood pressure is 122 over 76 mmHg and renal function is normal. She is not currently on any regular medication. What is the most appropriate initial disease-modifying pharmacological regimen