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ModerateRespiratoryAcute exacerbation of COPDuk-plab-1

A 70-year-old man with severe COPD (FEV1 35% predicted) presents with a 2-day history of increased breathlessness, cough and green sputum. On examination he is using accessory muscles and has widespread wheeze. Observations: respiratory rate 28 breaths per minute, oxygen saturation 86% on air, BP 138/76 mmHg and pulse 104 beats per minute. What is the most appropriate initial oxygen strategy?

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