Question

A 60-year-old woman presents to the emergency department within 90 minutes of onset of left-sided weakness and dysarthria. CT head shows no haemorrhage. She has no contraindication to thrombolysis and weighs 70 kg. According to Canadian Stroke Best Practices, what is the appropriate alteplase dose?

Accepted Answer

0.9 mg/kg IV (maximum 90 mg) with 10% as bolus and remainder over 60 minutes

Answer

0.6 mg/kg IV over 10 minutes, no bolus

Answer

1.0 mg/kg IV bolus, no infusion, maximum 100 mg

Answer

Fixed 50 mg IV over 60 minutes regardless of weight

Answer

0.25 mg/kg IV bolus up to 25 mg

Practice question

A 60-year-old woman presents to the emergency department within 90 minutes of onset of left-sided weakness and dysarthria. CT head shows no haemorrhage. She has no contraindication to thrombolysis and weighs 70 kg. According to Canadian Stroke Best Practices, what is the appropriate alteplase dose?