Question

A 30-year-old woman presents with chronic diarrhoea, weight loss and iron deficiency anaemia. Serology shows positive tissue transglutaminase IgA. What is the most appropriate next step to confirm the diagnosis?

Accepted Answer

Duodenal biopsy via upper GI endoscopy while still on a gluten-containing diet

Answer

Start a strict gluten-free diet immediately without further tests

Answer

HLA typing only

Answer

Colonoscopy alone

Answer

Capsule endoscopy

Practice question

A 30-year-old woman presents with chronic diarrhoea, weight loss and iron deficiency anaemia. Serology shows positive tissue transglutaminase IgA. What is the most appropriate next step to confirm the diagnosis?