Question

A 42-year-old woman presents with low mood, anhedonia, poor sleep, and impaired function for 2 months, meeting criteria for major depressive disorder. She has no prior episodes and no psychotic features. According to CANMAT 2023 guidelines, what is the most appropriate first-line treatment option?

Accepted Answer

Cognitive behavioural therapy or an SSRI, chosen collaboratively

Answer

Tricyclic antidepressant as first-line

Answer

Monoamine oxidase inhibitor as first-line

Answer

Antipsychotic monotherapy

Answer

Watchful waiting for 6 months

Practice question

A 42-year-old woman presents with low mood, anhedonia, poor sleep, and impaired function for 2 months, meeting criteria for major depressive disorder. She has no prior episodes and no psychotic features. According to CANMAT 2023 guidelines, what is the most appropriate first-line treatment option?