A 62-year-old man presents to a small rural emergency department with 2 hours of crushing central chest pain radiating to his left arm. His ECG shows 3 mm ST elevation in leads V2-V4 with reciprocal ST depression in leads III and aVF. The nearest PCI-capable hospital is 200 km away with an anticipated first-medical-contact-to-balloon time of about 3 hours despite immediate transfer. He has no history of bleeding, no recent stroke, and normal baseline bloodwork. Which reperfusion strategy is most appropriate now?