Question

A 50-year-old man with chronic hepatitis B has persistently elevated ALT and high viral load. Ultrasound shows no cirrhosis. Which is the most appropriate long-term antiviral therapy?

Accepted Answer

Tenofovir or entecavir as first-line nucleos(t)ide analogue therapy

Answer

Short course of interferon for 2 weeks

Answer

Lamivudine monotherapy indefinitely

Answer

No treatment is required unless cirrhosis develops

Answer

Ribavirin monotherapy

Practice question

A 50-year-old man with chronic hepatitis B has persistently elevated ALT and high viral load. Ultrasound shows no cirrhosis. Which is the most appropriate long-term antiviral therapy?