Question

A 28-year-old man with opioid use disorder on no current treatment presents requesting help after a non-fatal overdose. He is motivated to change. What is the most evidence-based pharmacologic option to reduce mortality and relapse?

Accepted Answer

Buprenorphine-naloxone maintenance therapy

Answer

Naloxone nasal spray alone

Answer

Short-term detoxification with clonidine

Answer

Tramadol substitution then taper

Answer

No pharmacologic therapy; psychotherapy only

Practice question

A 28-year-old man with opioid use disorder on no current treatment presents requesting help after a non-fatal overdose. He is motivated to change. What is the most evidence-based pharmacologic option to reduce mortality and relapse?