A 58-year-old man presents to a rural emergency department 60 minutes after onset of severe central chest pain. ECG shows 3 mm ST elevation in leads II, III and aVF. The nearest percutaneous coronary intervention (PCI) centre is 3 hours away even with urgent transfer. There are no contraindications to fibrinolysis. According to Canadian STEMI guidance, what is the most appropriate reperfusion strategy?