A 58-year-old man presents to a regional emergency department with 90 minutes of central crushing chest pain, diaphoresis and nausea. He has a history of hypertension and hypercholesterolaemia. His ECG shows ST elevation in leads II, III and aVF. His blood pressure is 135/80 mmHg and oxygen saturation is 98% on room air. There is no history of bleeding or aspirin allergy. What is the most appropriate immediate pharmacological intervention?