A 45-year-old woman is diagnosed with seropositive rheumatoid arthritis affecting hands and wrists with morning stiffness of 2 hours. According to Canadian rheumatology guidance, which is the most appropriate initial disease-modifying therapy?AHydroxychloroquine monotherapy in all patientsBNon-steroidal anti-inflammatory drugs aloneCMethotrexate as first-line DMARDDLong-term oral prednisone monotherapyEBiologic therapy as first-line in all patientsCheck my answer