A 64-year-old man presents to a rural emergency department 90 minutes after the onset of severe central chest pain radiating to his left arm, associated with diaphoresis and nausea. ECG shows 3 mm ST elevation in leads II, III, and aVF with reciprocal ST depression in I and aVL. The nearest percutaneous coronary intervention (PCI) centre is 300 km away by road, with an estimated transfer time of 4 hours. Which reperfusion strategy is most appropriate?