A 78-year-old woman with non-valvular atrial fibrillation, hypertension and type 2 diabetes has a CHA2DS2-VASc score of 4. She has no history of major bleeding. What is the most appropriate approach to stroke prevention?ANo antithrombotic therapy is requiredBAspirin 100 mg daily aloneCDual antiplatelet therapy with aspirin and clopidogrelDOral anticoagulation with a direct oral anticoagulantEIntermittent low molecular weight heparin injections during symptomatic episodes onlyCheck my answer