A 60-year-old man presents to the emergency department 45 minutes after onset of severe central chest pain radiating to his left arm with associated diaphoresis and nausea. ECG shows 3 mm ST elevation in leads II, III, aVF with reciprocal depression in aVL. High-sensitivity troponin is pending. He is at a metropolitan hospital with 24/7 PCI capability. What is the most appropriate reperfusion strategy?