A 62-year-old man presents to a metropolitan emergency department 45 minutes after onset of severe central chest pain radiating to the left arm, associated with diaphoresis and nausea. ECG shows 3 mm ST elevation in leads V2-V4 with reciprocal depression in II, III and aVF. Troponin results are pending. He has no contraindications to thrombolysis and the nearest PCI-capable centre is 4 hours away by road. What is the most appropriate immediate reperfusion strategy?