Question

A 60-year-old woman presents with chronic pruritus and fatigue. LFTs show cholestatic pattern with ALP 3 times normal and GGT elevated. AMA (anti-mitochondrial antibody) is strongly positive. According to guidelines, what is the first-line disease-modifying therapy?

Accepted Answer

Ursodeoxycholic acid

Answer

Azathioprine

Answer

Prednisolone

Answer

Methotrexate

Answer

No treatment; symptomatic care only

Practice question

A 60-year-old woman presents with chronic pruritus and fatigue. LFTs show cholestatic pattern with ALP 3 times normal and GGT elevated. AMA (anti-mitochondrial antibody) is strongly positive. According to guidelines, what is the first-line disease-modifying therapy?