MediumInfectious DiseasesAcute pyelonephritis with sepsisau-acemau-amc
A 70-year-old woman presents with fever, rigors and hypotension. She has right flank pain and dysuria. Temperature is 39.2 °C, blood pressure 90/55 mmHg, heart rate 120 beats/min and oxygen saturation 94% on room air. Urinalysis shows nitrites and leukocytes. You suspect septic shock secondary to pyelonephritis. According to Australian sepsis and antibiotic guidance, what is the most appropriate immediate antimicrobial management?