MediumCardiologyHeart failure with reduced ejection fractionau-racpau-amc
A 72-year-old man with a history of ischaemic cardiomyopathy (left ventricular ejection fraction 30%) presents to clinic. He is euvolaemic with NYHA class II symptoms. His current medications are perindopril 4 mg daily, bisoprolol 5 mg daily and frusemide 40 mg daily. Blood pressure is 120/70 mmHg, potassium 4.4 mmol/L, creatinine 95 µmol/L. According to contemporary heart failure management recommendations, which additional agent has the strongest mortality benefit and should be considered next?