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MediumRespiratoryChronic obstructive pulmonary diseaseau-racpau-amc

A 72-year-old man with COPD (FEV1 45% predicted) is already on a long-acting muscarinic antagonist (LAMA) inhaler. He remains symptomatic with mMRC dyspnoea score 3 and has had two moderate exacerbations requiring oral steroids in the last year. What is the most appropriate pharmacological escalation?

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