Question

A 40-year-old man with newly diagnosed HIV infection and a positive interferon-gamma release assay but normal chest X-ray has no symptoms. He has never been treated for TB. What is the most appropriate management of his TB status?

Accepted Answer

Treat latent TB infection with an appropriate regimen such as isoniazid-rifapentine

Answer

No treatment is required because chest X-ray is normal

Answer

Start standard 4-drug TB therapy for 6 months

Answer

Repeat IGRA in 1 year and defer action

Answer

Offer BCG vaccination

Practice question

A 40-year-old man with newly diagnosed HIV infection and a positive interferon-gamma release assay but normal chest X-ray has no symptoms. He has never been treated for TB. What is the most appropriate management of his TB status?