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MediumEndocrinologyPrimary hypothyroidism treatmentau-amcau-racgp

A 45-year-old woman presents with a 3-month history of fatigue, weight gain, cold intolerance and constipation. Examination shows dry skin and delayed ankle reflexes. TSH is 18 mIU/L (0.4-4.0) and free T4 is low. She is not pregnant. What is the most appropriate initial levothyroxine dose?

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