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MediumDermatologyChronic plaque psoriasisau-amcau-racgpau-racp

A 45-year-old man presents with well-demarcated erythematous plaques with silvery scale on the extensor surfaces of his elbows and knees and the scalp. Nails show pitting. Which systemic therapy is most appropriate to consider if topical treatment fails and disease is moderate to severe?

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