Question

A 35-year-old with recurrent gout flares and urate 9.0 mg/dL has CKD stage 2. Best long-term urate-lowering approach?

Accepted Answer

Allopurinol as first-line ULT with titration to serum urate <6 mg/dL

Answer

Probenecid first-line

Answer

Febuxostat is contraindicated with CKD

Answer

Avoid ULT; use colchicine PRN only

Answer

Urate-lowering therapy only if tophi are present

Practice question

A 35-year-old with recurrent gout flares and urate 9.0 mg/dL has CKD stage 2. Best long-term urate-lowering approach?