Question

A 64-year-old on apixaban for AF presents with massive GI bleeding and hypotension. Last apixaban dose 6 hours ago; creatinine normal. Which reversal strategy is preferred?

Accepted Answer

Andexanet alfa bolus and infusion

Answer

Fresh frozen plasma

Answer

Four-factor prothrombin complex concentrate (4F-PCC) 50 units/kg is first-line

Answer

Vitamin K 10 mg IV

Answer

Protamine sulfate

Practice question

A 64-year-old on apixaban for AF presents with massive GI bleeding and hypotension. Last apixaban dose 6 hours ago; creatinine normal. Which reversal strategy is preferred?