Question

A 55-year-old with HFrEF and symptomatic hypotension on GDMT is euvolemic. Which medication is most likely to be reduced/paused first to preserve mortality benefit?

Accepted Answer

Reduce vasodilators (e.g., ACEi/ARNI) cautiously only after attempting diuretic down-titration if possible; avoid stopping beta-blocker if feasible

Answer

Stop beta-blocker first

Answer

Increase diuretics

Answer

Stop SGLT2 inhibitor first

Answer

Stop MRA first

Practice question

A 55-year-old with HFrEF and symptomatic hypotension on GDMT is euvolemic. Which medication is most likely to be reduced/paused first to preserve mortality benefit?