Question

A 28-year-old with iron-deficiency anemia and chronic diarrhea is being evaluated for celiac disease while eating gluten. What initial test strategy is recommended?

Accepted Answer

Serum tissue transglutaminase IgA (tTG-IgA) with total IgA level

Answer

Proceed directly to small-bowel biopsy without serology

Answer

HLA-DQ2/DQ8 genotyping for all

Answer

Deamidated gliadin peptide IgG only

Answer

Start gluten-free diet before testing

Practice question

A 28-year-old with iron-deficiency anemia and chronic diarrhea is being evaluated for celiac disease while eating gluten. What initial test strategy is recommended?