Question

A 34-year-old with syphilis presents with painless genital ulcer; RPR positive, HIV negative; no neurologic signs. Optimal therapy?

Accepted Answer

Benzathine penicillin G 2.4 million units IM once

Answer

Aqueous crystalline penicillin G IV for 10-14 days

Answer

Doxycycline 100 mg BID for 28 days (first-line)

Answer

Ceftriaxone 1 g daily IV for 7 days

Answer

Azithromycin 2 g PO once

Practice question

A 34-year-old with syphilis presents with painless genital ulcer; RPR positive, HIV negative; no neurologic signs. Optimal therapy?