Question

A 62-year-old woman with recurrent gout flares and urate 9.2 mg/dL, eGFR 55. Best urate-lowering therapy?

Accepted Answer

Start allopurinol 100 mg daily and titrate to serum urate <6 mg/dL

Answer

Start febuxostat only if HLA-B*58:01 negative

Answer

Avoid allopurinol in CKD

Answer

Probenecid as first-line

Answer

Colchicine as chronic monotherapy for urate lowering

Practice question

A 62-year-old woman with recurrent gout flares and urate 9.2 mg/dL, eGFR 55. Best urate-lowering therapy?