A 48-year-old man presents to the emergency department with crushing substernal chest pain radiating to his left arm for 1 hour. ECG shows ST segment elevation of 3 mm in leads V2 to V4. He received aspirin 325 mg before arrival and has no contraindication to anticoagulation. A percutaneous coronary intervention capable facility is 30 minutes away. What is the most appropriate next step in reperfusion therapy?