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HardGastroenterologyPrimary sclerosing cholangitisus-abimus-usmle-step-2us-usmle-step-3

A 45-year-old man presents with jaundice, pruritus, and dark urine. He has a history of ulcerative colitis. Laboratory tests reveal a cholestatic liver enzyme pattern and elevated alkaline phosphatase. MRCP shows multifocal stricturing and dilation of intrahepatic and extrahepatic bile ducts. What is the most likely diagnosis?

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