Question

A 35-year-old nonpregnant patient with penicillin allergy (non-anaphylactic) tests positive for C. difficile infection, first episode, non-severe. Preferred initial therapy?

Accepted Answer

Fidaxomicin 200 mg PO twice daily for 10 days

Answer

Vancomycin 125 mg PO QID for 10 days

Answer

Metronidazole 500 mg PO TID for 10 days as first-line

Answer

IV vancomycin for 10 days

Answer

Stop all antibiotics; no CDI therapy

Practice question

A 35-year-old nonpregnant patient with penicillin allergy (non-anaphylactic) tests positive for C. difficile infection, first episode, non-severe. Preferred initial therapy?