Question

A 15-week pregnant patient is asymptomatic; urine culture from prenatal screening shows >=100,000 CFU/mL E. coli. What is the best management?

Accepted Answer

Single-dose fosfomycin is contraindicated in pregnancy

Answer

No treatment; observe

Answer

Treat with nitrofurantoin 100 mg PO twice daily for 5 days with test of cure

Answer

Defer treatment until third trimester

Answer

Start TMP-SMX now regardless of gestational age

Practice question

A 15-week pregnant patient is asymptomatic; urine culture from prenatal screening shows >=100,000 CFU/mL E. coli. What is the best management?