A 16-year-old who was small for gestational age has severe hypertension, hypokalaemic metabolic alkalosis, suppressed renin and suppressed aldosterone...

Question

A 16-year-old who was small for gestational age has severe hypertension, hypokalaemic metabolic alkalosis, suppressed renin and suppressed aldosterone. Renal function and serum cortisol are normal, and there is no liquorice or carbenoxolone exposure. Which result best supports inherited apparent mineralocorticoid excess?

Accepted Answer

Raised urinary free cortisol-to-cortisone ratio

Answer

Raised plasma aldosterone-to-renin ratio

Answer

Raised plasma 11-deoxycortisol concentration

Answer

Raised urinary normetanephrine concentration

Answer

Raised urinary free cortisol concentration

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