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Moderate"IDSA/SHEA 2021 suggests fidaxomicin over vancomycin for initial CDI due to lower recurrence; vancomycin remains acceptable alternative; metronidazole is no longer preferred; rifaximin is not first‑line; bezlotoxumab is adjunctiveIDSA/SHEA Guideline (2021): Clostridioides difficile Infection - Focused Update"infectious diseases"

A 72-year-old inpatient with a first episode of non-severe C. difficile infection (WBC 11,000/µL, creatinine 1.1 mg/dL). Preferred initial therapy?

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