Question

In a stable outpatient with chronic HFrEF (LVEF 30%) and NYHA class II symptoms on no HF medications, which set of drug classes constitutes the contemporary core pillars of guideline-directed medical therapy to reduce mortality and HF hospitalization?

Accepted Answer

ACE inhibitor + beta-blocker + loop diuretic + digoxin

Answer

ARNI (sacubitril/valsartan) + evidence-based beta-blocker + MRA + SGLT2 inhibitor

Answer

Hydralazine/isosorbide dinitrate + loop diuretic + ivabradine + omega-3

Answer

Non-DHP calcium channel blocker + loop diuretic + nitrate + aspirin

Answer

None of the above

Practice question

In a stable outpatient with chronic HFrEF (LVEF 30%) and NYHA class II symptoms on no HF medications, which set of drug classes constitutes the contemporary core pillars of guideline-directed medical therapy to reduce mortality and HF hospitalization?