An adult with COPD and eosinophils 0.36 × 10⁹/L takes ICS–LABA–LAMA. In the year before mepolizumab there was 1 severe and 2 moderate exacerbations. A...

Question

An adult with COPD and eosinophils 0.36 × 10⁹/L takes ICS–LABA–LAMA. In the year before mepolizumab there was 1 severe and 2 moderate exacerbations. After 12 months there is 1 severe and 3 moderate exacerbations. What follows?

Accepted Answer

Stop mepolizumab because moderate exacerbations increased

Answer

Continue mepolizumab because severe events did not increase

Answer

Continue mepolizumab because eosinophils remain above 0.3 × 10⁹/L

Answer

Stop mepolizumab only if severe exacerbations increase to two

Answer

Continue mepolizumab until the 24-month exacerbation review

Hypertension — MRCP Part 1 MCQ

An adult with COPD and eosinophils 0.36 × 10⁹/L takes ICS–LABA–LAMA. In the year before mepolizumab there was 1 severe and 2 moderate exacerbations. After 12 months there is 1 severe and 3 moderate exacerbations. What follows?