A 62-year-old with COPD and frequent exacerbations despite maximal inhaled therapy asks about roflumilast. When is it considered?AIn chronic bronchitis phenotype with frequent exacerbations and FEV1 <50% despite optimized therapyBIn emphysema phenotype onlyCAs first-line therapyDWhen eosinophils are high (>300/µL)EIn asthma instead of ICSCheck my answer