Question

A 58-year-old with tophaceous gout and recurrent flares chooses urate-lowering therapy. Best target and initial agent?

Accepted Answer

Target serum urate <6 mg/dL; start allopurinol and titrate

Answer

Target serum urate <7 mg/dL; start febuxostat

Answer

No target; fixed-dose allopurinol

Answer

Start probenecid first-line regardless of renal function

Answer

Start pegloticase first-line

Practice question

A 58-year-old with tophaceous gout and recurrent flares chooses urate-lowering therapy. Best target and initial agent?