Question

A 44-year-old newly diagnosed RA (moderate activity, normal hepatic/renal function) asks about first-line disease-modifying therapy. What is recommended?

Accepted Answer

Methotrexate monotherapy as initial csDMARD

Answer

Hydroxychloroquine monotherapy for all moderate-to-high activity

Answer

TNF-alpha inhibitor first-line in methotrexate-naïve

Answer

Chronic oral prednisone 10-15 mg/day as maintenance

Answer

Leflunomide preferred over methotrexate for cost

Practice question

A 44-year-old newly diagnosed RA (moderate activity, normal hepatic/renal function) asks about first-line disease-modifying therapy. What is recommended?