Question

A 59-year-old man with HFrEF (EF 30%) is euvolemic on lisinopril and metoprolol succinate. According to current U.S. guidance, which additional therapies should be part of foundational quadruple therapy?

Accepted Answer

Add ARNI (sacubitril/valsartan), MRA, and SGLT2 inhibitor

Answer

Add isosorbide mononitrate and hydralazine only

Answer

Add furosemide, digoxin, and amiodarone

Answer

Add ivabradine and vericiguat only

Answer

Switch to ACE inhibitor plus nitrates

Practice question

A 59-year-old man with HFrEF (EF 30%) is euvolemic on lisinopril and metoprolol succinate. According to current U.S. guidance, which additional therapies should be part of foundational quadruple therapy?