Question

A 48-year-old with early rheumatoid arthritis (seropositive, high disease activity) and normal liver/renal function seeks disease-modifying therapy. Best initial approach?

Accepted Answer

Sulfasalazine only for 3 months then reassess

Answer

Hydroxychloroquine monotherapy

Answer

Long-term prednisone monotherapy

Answer

Start TNF inhibitor immediately without csDMARD

Answer

Begin methotrexate with treat-to-target strategy

Practice question

A 48-year-old with early rheumatoid arthritis (seropositive, high disease activity) and normal liver/renal function seeks disease-modifying therapy. Best initial approach?