Question

A 35‑year‑old woman with chronic diarrhea on a gluten‑containing diet is evaluated for celiac disease. Which initial test strategy is preferred?

Accepted Answer

tTG‑IgA with total serum IgA

Answer

Anti‑endomysial IgG only

Answer

HLA‑DQ2/8 genotyping as first step

Answer

Small bowel biopsy without serology

Answer

Fecal calprotectin

Practice question

A 35‑year‑old woman with chronic diarrhea on a gluten‑containing diet is evaluated for celiac disease. Which initial test strategy is preferred?